USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: IDHC_HUMAN USC-OGP 2-DE database:  IDHC_HUMAN IDHC_HUMAN General information about the entry View entry in simple text format Entry name IDHC_HUMAN Primary accession number O75874 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic; Short=IDH; EC=1.1.1.42; AltName: Full=Cytosolic NADP-isocitrate dehydrogenase; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase;. Gene name Name=IDH1 Synonyms=PICD Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0405: pI=6.60; Mw=43377 Cross-references UniProtKB/Swiss-Prot O75874; IDHC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name IDHC_HUMAN Primary accession number O75874 Secondary accession number(s) Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8 Sequence was last modified on  July 11, 2002 (version 2) Annotations were last modified on  March 15, 2017 (version 182) Name and origin of the protein Description RecName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic; Short=IDH; EC=1.1.1.42; AltName: Full=Cytosolic NADP-isocitrate dehydrogenase; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase; Gene name Name=IDH1 Synonyms=PICD Encoded on Name=IDH1; Synonyms=PICD Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Peroxisome; Phosphoprotein; Polymorphism; Reference proteome; Tricarboxylic acid cycle. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF020038; AAD02918.1; -; mRNA EMBL AF113917; AAD29284.1; -; mRNA EMBL AL136702; CAB66637.1; -; mRNA EMBL CR541695; CAG46496.1; -; mRNA EMBL BX537411; CAD97653.1; -; mRNA EMBL AC016697; AAX93221.1; -; Genomic_DNA EMBL CH471063; EAW70439.1; -; Genomic_DNA EMBL BC012846; AAH12846.1; -; mRNA EMBL BC093020; AAH93020.1; -; mRNA EMBL U62389; AAB17375.1; -; mRNA CCDS CCDS2381.1; -; . PIR T46280; T46280; . RefSeq NP_001269315.1; NM_001282386.1; . RefSeq NP_001269316.1; NM_001282387.1; . RefSeq NP_005887.2; NM_005896.3; . UniGene Hs.593422; -; . PDB 1T09; X-ray; 2.70 A; A/B=1-414 PDB 1T0L; X-ray; 2.41 A; A/B/C/D=1-414 PDB 3INM; X-ray; 2.10 A; A/B/C=1-414 PDB 3MAP; X-ray; 2.80 A; A/B=1-414 PDB 3MAR; X-ray; 3.41 A; A/B=1-414 PDB 3MAS; X-ray; 3.20 A; A/B=1-414 PDB 4I3K; X-ray; 3.31 A; A/B=1-414 PDB 4I3L; X-ray; 3.29 A; A/B=1-414 PDB 4KZO; X-ray; 2.20 A; A/B/C=1-414 PDB 4L03; X-ray; 2.10 A; A/B/C=1-414 PDB 4L04; X-ray; 2.87 A; A/B/C/D/E/F=1-414 PDB 4L06; X-ray; 2.28 A; A/B/C/D/E/F=1-414 PDB 4UMX; X-ray; 1.88 A; A/B=1-414 PDB 4UMY; X-ray; 2.07 A; A/B=1-414 PDB 4XRX; X-ray; 3.20 A; A/B=1-414 PDB 4XS3; X-ray; 3.29 A; A/B=1-414 PDB 5DE1; X-ray; 2.25 A; A/B=2-414 PDB 5GIR; X-ray; 1.93 A; C/D=126-137 PDB 5K10; EM; 3.80 A; A/B=3-413 PDB 5K11; EM; 3.80 A; A/B=3-413 PDB 5L57; X-ray; 2.69 A; A=1-414 PDB 5L58; X-ray; 3.04 A; A=1-414 PDB 5TQH; X-ray; 2.20 A; A/B/C/D=1-414 PDBsum 1T09; -; . PDBsum 1T0L; -; . PDBsum 3INM; -; . PDBsum 3MAP; -; . PDBsum 3MAR; -; . PDBsum 3MAS; -; . PDBsum 4I3K; -; . PDBsum 4I3L; -; . PDBsum 4KZO; -; . PDBsum 4L03; -; . PDBsum 4L04; -; . PDBsum 4L06; -; . PDBsum 4UMX; -; . PDBsum 4UMY; -; . PDBsum 4XRX; -; . PDBsum 4XS3; -; . PDBsum 5DE1; -; . PDBsum 5GIR; -; . PDBsum 5K10; -; . PDBsum 5K11; -; . PDBsum 5L57; -; . PDBsum 5L58; -; . PDBsum 5TQH; -; . ProteinModelPortal O75874; -; . SMR O75874; -; . BioGrid 109643; 50; . DIP DIP-59311N; -; . IntAct O75874; 4; . MINT MINT-4998878; -; . STRING 9606.ENSP00000260985; -; . BindingDB O75874; -; . ChEMBL CHEMBL2007625; -; . DrugBank DB03461; 2'-Monophosphoadenosine 5'-Diphosphoribose; . DrugBank DB01727; Isocitric Acid; . GuidetoPHARMACOLOGY 2884; -; . iPTMnet O75874; -; . PhosphoSitePlus O75874; -; . SwissPalm O75874; -; . BioMuta IDH1; -; . OGP O75874; -; . REPRODUCTION-2DPAGE IPI00027223; -; . UCD-2DPAGE O75874; -; . EPD O75874; -; . PaxDb O75874; -; . PeptideAtlas O75874; -; . PRIDE O75874; -; . DNASU 3417; -; . Ensembl ENST00000345146; ENSP00000260985; ENSG00000138413; . Ensembl ENST00000415913; ENSP00000390265; ENSG00000138413; . Ensembl ENST00000446179; ENSP00000410513; ENSG00000138413; . GeneID 3417; -; . KEGG hsa:3417; -; . CTD 3417; -; . DisGeNET 3417; -; . GeneCards IDH1; -; . H-InvDB HIX0161877; -; . HGNC HGNC:5382; IDH1; . HPA CAB033218; -; . HPA CAB062556; -; . HPA HPA035248; -; . HPA HPA057936; -; . MalaCards IDH1; -; . MIM 137800; phenotype; . MIM 147700; gene; . neXtProt NX_O75874; -; . OpenTargets ENSG00000138413; -; . Orphanet 296; Enchondromatosis; . Orphanet 251579; Giant cell glioblastoma; . Orphanet 251576; Gliosarcoma; . Orphanet 163634; Maffucci syndrome; . Orphanet 99646; Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria; . PharmGKB PA29630; -; . eggNOG KOG1526; Eukaryota; . eggNOG COG0538; LUCA; . GeneTree ENSGT00390000012547; -; . HOGENOM HOG000019858; -; . HOVERGEN HBG006119; -; . InParanoid O75874; -; . KO K00031; -; . OMA HNFESCG; -; . OrthoDB EOG091G06IY; -; . PhylomeDB O75874; -; . TreeFam TF300428; -; . BioCyc MetaCyc:HS06502-MONOMER; -; . BRENDA 1.1.1.42; 2681; . Reactome R-HSA-2978092; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; . Reactome R-HSA-389542; NADPH regeneration; . Reactome R-HSA-6798695; Neutrophil degranulation; . SABIO-RK O75874; -; . ChiTaRS IDH1; human; . EvolutionaryTrace O75874; -; . GeneWiki IDH1; -; . GenomeRNAi 3417; -; . PRO PR:O75874; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000138413; -; . CleanEx HS_IDH1; -; . ExpressionAtlas O75874; baseline and differential; . Genevisible O75874; HS; . GO GO:0005737; C:cytoplasm; IDA:LIFEdb; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0005739; C:mitochondrion; IEA:Ensembl; . GO GO:0005782; C:peroxisomal matrix; TAS:Reactome; . GO GO:0005777; C:peroxisome; IDA:UniProtKB; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:1904724; C:tertiary granule lumen; TAS:Reactome; . GO GO:0051990; F:(R)-2-hydroxyglutarate dehydrogenase activity; EXP:Reactome; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IDA:UniProtKB; . GO GO:0000287; F:magnesium ion binding; IDA:UniProtKB; . GO GO:0051287; F:NAD binding; IEA:InterPro; . GO GO:0050661; F:NADP binding; IEA:Ensembl; . GO GO:0042803; F:protein homodimerization activity; IPI:UniProtKB; . GO GO:0005102; F:receptor binding; IPI:UniProtKB; . GO GO:0006103; P:2-oxoglutarate metabolic process; IDA:UniProtKB; . GO GO:0008585; P:female gonad development; IEA:Ensembl; . GO GO:0006749; P:glutathione metabolic process; IEA:Ensembl; . GO GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW; . GO GO:0006102; P:isocitrate metabolic process; IDA:UniProtKB; . GO GO:0006740; P:NADPH regeneration; TAS:Reactome; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0071071; P:regulation of phospholipid biosynthetic process; IEA:Ensembl; . GO GO:0060696; P:regulation of phospholipid catabolic process; IEA:Ensembl; . GO GO:0006979; P:response to oxidative stress; IEA:Ensembl; . GO GO:0048545; P:response to steroid hormone; IEA:Ensembl; . GO GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW; . Gene3D 3.40.718.10; -; 1; . InterPro IPR019818; IsoCit/isopropylmalate_DH_CS; . InterPro IPR004790; Isocitrate_DH_NADP; . InterPro IPR024084; IsoPropMal-DH-like_dom; . PANTHER PTHR11822; PTHR11822; 1; . Pfam PF00180; Iso_dh; 1; . PIRSF PIRSF000108; IDH_NADP; 1; . SMART SM01329; Iso_dh; 1; . TIGRFAMs TIGR00127; nadp_idh_euk; 1; . PROSITE PS00470; IDH_IMDH; 1; .

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